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Depression (major depressive disorder or clinical depression) is a common but serious mood disorder. Research suggests that depression doesn’t spring from simply having too much or too little of certain brain chemicals. Rather, there are many possible causes of depression, including faulty mood regulation by the brain, genetic vulnerability, stressful life events, medications, and medical problems. What Is Depression? Depression (major depressive disorder) is a common and serious medical illness that negatively affects how you feel, the way you think and how you act. What happens in the brain during depression? The influx of cortisol triggered by depression also causes the amygdala to enlarge. This is a part of the brain associated with emotional responses. When it becomes larger and more active, it causes sleep disturbances, changes in activity levels, and changes in other hormones. What are the causes of depression? Meaningful Work Other People Meaningful Values Childhood Trauma Stat...